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Background: The dorsal anterior cingulate cortex (dACC) is a key network hub for cognitive control and environmental adaptation. Previous studies have shown that task-based functional activity in this area is constrained by individual differences in sulcal pattern, a morphologic feature of cortex anatomy determined during fetal life and stable throughout development.

Methods: By using anatomical magnetic resonance imaging and seed-based resting-state functional connectivity (rsFC), we explored the influence of sulcal pattern variability on the functional architecture of the dACC in a sample of healthy adults aged 20–80 years (n = 173).

Results: Overall, rsFC was associated with individual differences in sulcal pattern. Furthermore, rsFC was modulated by the age–sulcal pattern interaction.

Conclusion: Our results suggest a relationship between brain structure and function that partly traces back to early stages of …