作者
Sybil A McAuley, Melissa H Lee, Barbora Paldus, Sara Vogrin, Martin I De Bock, Mary B Abraham, Leon A Bach, Morton G Burt, Neale D Cohen, Peter G Colman, Elizabeth A Davis, Christel Hendrieckx, D Jane Holmes-Walker, Joey Kaye, Anthony C Keech, Kavita Kumareswaran, Richard J MacIsaac, Roland W McCallum, Catriona M Sims, Jane Speight, Stephen N Stranks, Vijaya Sundararajan, Steven Trawley, Glenn M Ward, Alicia J Jenkins, Timothy W Jones, David N O’Neal
发表日期
2020/12/1
期刊
Diabetes care
卷号
43
期号
12
页码范围
3024-3033
出版商
American Diabetes Association
简介
OBJECTIVE
To investigate glycemic and psychosocial outcomes with hybrid closed-loop (HCL) versus user-determined insulin dosing with multiple daily injections (MDI) or insulin pump (i.e., standard therapy for most adults with type 1 diabetes).
RESEARCH DESIGN AND METHODS
Adults with type 1 diabetes using MDI or insulin pump without continuous glucose monitoring (CGM) were randomized to 26 weeks of HCL (Medtronic 670G) or continuation of current therapy. The primary outcome was masked CGM time in range (TIR; 70–180 mg/dL) during the final 3 weeks.
RESULTS
Participants were randomized to HCL (n = 61) or control (n = 59). Baseline mean (SD) age was 44.2 (11.7) years, HbA1c was 7.4% (0.9%) (57 [10] mmol/mol), 53% were women, and 51% used MDI. HCL TIR increased from (baseline) 55% (13%) to (26 weeks) 70% (10%) with the …
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SA McAuley, MH Lee, B Paldus, S Vogrin, MI De Bock… - Diabetes care, 2020