作者
Bruno Araújo Serra Pinto, Thamys Marinho Melo, Karla Frida Torres Flister, Lucas Martins França, Daniela Kajihara, Vanessa Ribeiro Moreira, Silma Regina Ferreira Pereira, Francisco Rafael Martins Laurindo, Antonio Marcus De Andrade Paes
发表日期
2017/4
期刊
The FASEB Journal
卷号
31
页码范围
636.34-636.34
出版商
The Federation of American Societies for Experimental Biology
简介
Background
Metabolic syndrome (MS)‐related conditions promotes endoplasmic reticulum stress (ERS) in order to control their deleterious effects through activation of adaptive responses known as Unfolded Protein Response (UPR). However, under chronic stress, UPR can evolve to apoptotic pathways. Previously, we have shown that MS induced by high‐sucrose diet triggers the ERS and apoptotic pathways in hippocampus and lead to motor and behavioral impairments in young rats.
Aims
In the present study we sought to investigate if sustained exposure to such diet is capable to intensify those metabolic disturbances and anticipate neurological impairments in adult rats.
Methods
Thus, weaned Wistar rats were divided in two groups: the control group (CTR, n=7), fed with a standard chow; and obese group (HSD, n=7), fed with high‐sucrose diet (25% sucrose). Both groups were followed for 6 months and …
学术搜索中的文章
BAS Pinto, TM Melo, KFT Flister, LM França, D Kajihara… - The FASEB Journal, 2017