作者
Stefan Pilz, Andreas Tomaschitz, Winfried März, Christiane Drechsler, Eberhard Ritz, Armin Zittermann, Etienne Cavalier, Thomas R Pieber, Joan M Lappe, William B Grant, Michael F Holick, Jacqueline M Dekker
发表日期
2011/11
来源
Clinical endocrinology
卷号
75
期号
5
页码范围
575-584
出版商
Blackwell Publishing Ltd
简介
A poor vitamin D status, i.e. low serum levels of 25‐hydroxyvitamin D [25(OH)D], is common in the general population. This finding is of concern not only because of the classic vitamin D effects on musculoskeletal outcomes, but also because expression of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in the heart and blood vessels suggests a role of vitamin D in the cardiovascular system. VDR‐knockout mice suffer from cardiovascular disease (CVD), and various experimental studies suggest cardiovascular protection by vitamin D, including antiatherosclerotic, anti‐inflammatory and direct cardio‐protective actions, beneficial effects on classic cardiovascular risk factors as well as suppression of parathyroid hormone (PTH) levels. In epidemiological studies, low levels of 25(OH)D are associated with increased risk of CVD and mortality. Data from randomized controlled trials (RCTs) are sparse …
引用总数
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S Pilz, A Tomaschitz, W März, C Drechsler, E Ritz… - Clinical endocrinology, 2011