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A rapid growth in medical ultrasound database makes it difficult for medical practitioners to manage and search relevant data with good efficiency. Hence, a novel image retrieval technique using Mean Distance Local Binary Pattern (Mean Distance LBP) has been proposed for content-based image retrieval. The conventional local binary pattern (LBP) converts every pixel of image into a binary pattern based on their relationship with neighbourhood pixels. The proposed feature descriptor differs from local binary pattern as it transforms the mutual relationship of all neighbouring pixels in a binary pattern based on their standard deviation templates as well as Euclidean distance from the center pixel. Color feature and Gray Level Co-occurrence Matrix have also been used in this work. To prove the excellence of the proposed method, experiments have been conducted on two different databases of natural …