作者
Sunny H Wong, Thomas NY Kwong, Tai-Cheong Chow, Arthur KC Luk, Rudin ZW Dai, Geicho Nakatsu, Thomas YT Lam, Lin Zhang, Justin CY Wu, Francis KL Chan, Simon SM Ng, Martin CS Wong, Siew C Ng, William KK Wu, Jun Yu, Joseph JY Sung
发表日期
2017/8/1
期刊
Gut
卷号
66
期号
8
页码范围
1441-1448
出版商
BMJ Publishing Group
简介
Objective
There is a need for an improved biomarker for colorectal cancer (CRC) and advanced adenoma. We evaluated faecal microbial markers for clinical use in detecting CRC and advanced adenoma.
Design
We measured relative abundance of Fusobacterium nucleatum (Fn), Peptostreptococcus anaerobius (Pa) and Parvimonas micra (Pm) by quantitative PCR in 309 subjects, including 104 patients with CRC, 103 patients with advanced adenoma and 102 controls. We evaluated the diagnostic performance of these biomarkers with respect to faecal immunochemical test (FIT), and validated the results in an independent cohort of 181 subjects.
Results
The abundance was higher for all three individual markers in patients with CRC than controls (p<0.001), and for marker Fn in patients with advanced adenoma than controls (p=0.022). The marker Fn, when combined with FIT, showed superior sensitivity (92.3% vs …
学术搜索中的文章
SH Wong, TNY Kwong, TC Chow, AKC Luk, RZW Dai… - Gut, 2017