作者
Sergey Nejentsev, Joanna MM Howson, Neil M Walker, Jeffrey Szeszko, Sarah F Field, Helen E Stevens, Pamela Reynolds, Matthew Hardy, Erna King, Jennifer Masters, John Hulme, Lisa M Maier, Deborah Smyth, Rebecca Bailey, Jason D Cooper, Gloria Ribas, R Duncan Campbell, David G Clayton, John A Todd, Analysis committee Barrett Jeffrey C. 6 Burton Paul R. 4 Davison Dan 14 Donnelly Peter 14 Easton Doug 15 Evans David 6 Leung Hin-Tak 5 Marchini Jonathan L. 14 Morris Andrew P. 6 Spencer Chris CA 14 Tobin Martin D. 4 Cardon Lon R. 6 Clayton David G. 5, 1958 birth cohort controls Jones Richard W. 21 McArdle Wendy L. 21 Ring Susan M. 21 Strachan David P. 22 Pembrey Marcus 21 23, Rheumatoid arthritis Barton Anne 43 The Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hider, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah PM Symmons, Wendy Thomson, Jane Worthington, David G Clayton, David B Dunger, Sarah Nutland, Helen E Stevens, Neil M Walker, Barry Widmer, John A Todd, Timothy M Frayling, Rachel M Freathy, Hana Lango, John RB Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicholas J Timpson, Eleftheria Zeggini, Mark I McCarthy, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian VS Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Jayne A Franklyn, Joanne M Heward, Matthew J Simmonds, Stephen CL Gough, Sheila Seal, Breast Cancer Susceptibility Collaboration (UK), Michael R Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J Sawcer, Alastair Compston, David Conway, Muminatou Jallow, Melanie Newport, Giorgio Sirugo, Kirk A Rockett, Dominic P Kwiatkowski, Claire Bryan, Suzannah J Bumpstead, Amy Chaney, Kate Downes, Jilur Ghori, Rhian Gwilliam, Sarah E Hunt, Michael Inouye, Andrew Keniry, Emma King, Ralph McGinnis, Simon Potter, Rathi Ravindrarajah, Pamela Whittaker, David Withers, Panos Deloukas, Hin-Tak Leung, Sarah Nutland, Helen E Stevens, Neil M Walker, John A Todd, Doug Easton, David G Clayton, Paul R Burton, Martin D Tobin, Jeffrey C Barrett, David Evans, Andrew P Morris, Lon R Cardon, Niall J Cardin, Dan Davison, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B Hallgrimsdóttir, Bryan N Howie, Jonathan L Marchini, Chris CA Spencer, Zhan Su, Yik Ying Teo, Damjan Vukcevic, Peter Donnelly, David Bentley, Matthew A Brown, Lon R Cardon, Mark Caulfield, David G Clayton, Alistair Compston, Nick Craddock, Panos Deloukas, Peter Donnelly, Martin Farrall, Stephen CL Gough, Alistair S Hall, Andrew T Hattersley, Adrian VS Hill, Dominic P Kwiatkowski, Christopher G Mathew, Mark I McCarthy, Willem H Ouwehand
发表日期
2007/12/6
期刊
Nature
卷号
450
期号
7171
页码范围
887-892
出版商
Nature Publishing Group UK
简介
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs ), but these genes cannot completely explain the association between type 1 diabetes and the MHC region,,,,,,,. Owing to the region’s extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods—recursive …
引用总数
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S Nejentsev, JMM Howson, NM Walker, J Szeszko… - Nature, 2007