作者
Eleftheria Zeggini, Michael N Weedon, Cecilia M Lindgren, Timothy M Frayling, Katherine S Elliott, Hana Lango, Nicholas J Timpson, John RB Perry, Nigel W Rayner, Rachel M Freathy, Jeffrey C Barrett, Beverley Shields, Andrew P Morris, Sian Ellard, Christopher J Groves, Lorna W Harries, Jonathan L Marchini, Katharine R Owen, Beatrice Knight, Lon R Cardon, Mark Walker, Graham A Hitman, Andrew D Morris, Alex SF Doney, Mark I McCarthy, Andrew T Hattersley
发表日期
2007/6/1
期刊
Science
卷号
316
期号
5829
页码范围
1336-1341
出版商
American Association for the Advancement of Science
简介
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the …
引用总数
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E Zeggini, MN Weedon, CM Lindgren, TM Frayling… - Science, 2007