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This paper presents a method of improving the Transcranial Doppler (TCD) signal by removing harmonic interferences. Such interferences, originating from medical equipment using the high power HF signals are common in a clinical environment, especially in the neighborhood of the operating theater. The Adaptive Interference Canceler based on the NLMS FIR filter has been used. The reference signal was obtained by delaying of the original TCD signal. The presented method allows significant improvement of a seriously disturbed TCD signal.