作者
Juan Carlos González-Sánchez, Mustafa FR Ibrahim, Ivo C Leist, Kyle R Weise, Robert B Russell
发表日期
2021/7/2
期刊
Nucleic Acids Research
卷号
49
期号
W1
页码范围
W366-W374
出版商
Oxford University Press
简介
Advances in DNA sequencing and proteomics mean that researchers must now regularly interrogate thousands of positional gene/protein changes in order to find those relevant for potential clinical application or biological insights. The abundance of already known information on protein interactions, mechanism, and tertiary structure provides the possible means to understand these changes rapidly, though a careful and systematic integration of these diverse datasets is first needed. For this purpose, we developed Mechnetor, a tool that allows users to quickly explore and visualize integrated mechanistic data for proteins or interactions of interest. Central to the system is a careful cataloguing of diverse sources of protein interaction mechanism, and an efficient means to visualize interactions between relevant and/or known protein regions. The result is a finer resolution interaction network that provides more …
引用总数
20212022202320241212
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