作者
Wadha A Al Muftah, Mashael Al-Shafai, Shaza B Zaghlool, Alessia Visconti, Pei-Chien Tsai, Pankaj Kumar, Tim Spector, Jordana Bell, Mario Falchi, Karsten Suhre
发表日期
2016/12
期刊
Clinical epigenetics
卷号
8
页码范围
1-10
出版商
BioMed Central
简介
Background
The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changing environment are investigated for their role in the pathogenesis of these complex diseases. Epigenome-wide association studies (EWASs) have revealed significant associations of T2D, obesity, and BMI with DNA methylation. However, populations from the Middle East, where T2D and obesity rates are highest worldwide, have not been investigated so far.
Methods
We performed the first EWAS in an Arab population with T2D and BMI and attempted to replicate 47 EWAS associations previously reported in Caucasians. We used the Illumina Infinium HumanMethylation450 BeadChip to quantify DNA methylation in whole blood DNA …
学术搜索中的文章
WA Al Muftah, M Al-Shafai, SB Zaghlool, A Visconti… - Clinical epigenetics, 2016