作者
Cathal John Hannan, Daniel Lewis, Claire O'Leary, Mueez Waqar, David Brough, Kevin N Couper, Douglas P Dyer, Andy Vail, Calvin Heal, Joshua Macarthur, Christopher Cooper, Charlotte Hammerbeck-Ward, D Gareth Evans, Scott A Rutherford, Simon K Lloyd, Simon Richard Mackenzie Freeman, David John Coope, Andrew T King, Omar Nathan Pathmanaban
发表日期
2023/3/1
期刊
Neurosurgery
卷号
92
期号
3
页码范围
581-589
出版商
LWW
简介
BACKGROUND:
There is evidence that macrophage infiltration in the tumor microenvironment promotes vestibular schwannoma (VS) growth. Efficacy of bevacizumab in NF2-associated VS demonstrates the value of therapies targeting the microvascular tumor microenvironment, and tumor-associated macrophages (TAMs) may represent another druggable target.
OBJECTIVE:
To characterize the relationship between growth, TAM infiltration, and circulating monocyte chemokines in a large cohort of patients with VS.
METHODS:
Immunostaining for Iba1 (macrophages), CD31 (endothelium), and fibrinogen (permeability) was performed on 101 growing and 19 static sporadic VS. The concentrations of monocyte-specific chemokines were measured in the plasma of 50 patients with growing VS and 25 patients with static VS.
RESULTS:
The Iba1+ cell count was significantly higher in growing as compared with static VS …
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CJ Hannan, D Lewis, C O'Leary, M Waqar, D Brough… - Neurosurgery, 2023