作者
Zhemin Zhou, Inge Lundstrøm, Alicia Tran-Dien, Sebastián Duchêne, Nabil-Fareed Alikhan, Martin J Sergeant, Gemma Langridge, Anna K Fotakis, Satheesh Nair, Hans K Stenøien, Stian S Hamre, Sherwood Casjens, Axel Christophersen, Christopher Quince, Nicholas R Thomson, François-Xavier Weill, Simon YW Ho, M Thomas P Gilbert, Mark Achtman
发表日期
2018/8/6
期刊
Current Biology
卷号
28
期号
15
页码范围
2420-2428. e10
出版商
Elsevier
简介
Salmonella enterica serovar Paratyphi C causes enteric (paratyphoid) fever in humans. Its presentation can range from asymptomatic infections of the blood stream to gastrointestinal or urinary tract infection or even a fatal septicemia [1]. Paratyphi C is very rare in Europe and North America except for occasional travelers from South and East Asia or Africa, where the disease is more common [2, 3]. However, early 20th-century observations in Eastern Europe [3, 4] suggest that Paratyphi C enteric fever may once have had a wide-ranging impact on human societies. Here, we describe a draft Paratyphi C genome (Ragna) recovered from the 800-year-old skeleton (SK152) of a young woman in Trondheim, Norway. Paratyphi C sequences were recovered from her teeth and bones, suggesting that she died of enteric fever and demonstrating that these bacteria have long caused invasive salmonellosis in Europeans …
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