作者
Safi U Khan, Muhammad Zia Khan, Charumathi Raghu Subramanian, Haris Riaz, Muhammad U Khan, Ahmad Naeem Lone, Muhammad Shahzeb Khan, Eve-Marie Benson, Mohamad Alkhouli, Michael J Blaha, Roger S Blumenthal, Martha Gulati, Erin D Michos
发表日期
2020/5/1
来源
JAMA Network Open
卷号
3
期号
5
页码范围
e205202-e205202
出版商
American Medical Association
简介
Importance
Randomized clinical trials (RCTs) of lipid-lowering therapies form the evidence base for national and international guidelines. However, concerns exist that women and older patients are underrepresented in RCTs.
Objective
To determine the trends of representation of women and older patients (≥65 years) in RCTs of lipid-lowering therapies from 1990 to 2018.
Data Sources
The electronic databases of MEDLINE and ClinicalTrials.gov were searched from January 1990 through December 2018.
Study Selection
RCTs of lipid-lowering therapies with sample sizes of at least 1000 patients and follow-up periods of at least 1 year were included.
Data Extraction and Synthesis
Two independent investigators abstracted the data on a standard data collection form.
Main Outcomes and Measures
Patterns of representation of women and older adults were examined overall in lipid-lowering RCTs and according to RCT …
学术搜索中的文章
SU Khan, MZ Khan, CR Subramanian, H Riaz… - JAMA Network Open, 2020