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This paper presents a five-phase taxonomy of systematic procedures to enable flexibility in the design and management of engineering systems operating under uncertainty. The taxonomy integrates contributions from surveys, individual articles, and books from the literature on engineering design, manufacturing, product development, and real options analysis obtained from professional e-index search engines. Thirty design procedures were classified based on the kind of early conceptual activities they support: baseline design, uncertainty recognition, concept generation, design space exploration, and process management. Each procedure is evaluated based on ease of use to enable flexibility analysis, whether it can be used directly in collaborative design activities, and has a proven applicability record in industry and research. The organizing principles integrate the procedures into a cohesive and systematic …