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Childhood lymphoblastic T-cell lymphoma (T-LBL) represents about one-third of pediatric non-Hodgkin’s lymphomas, and it originates from lymphoid progenitor cells arrested at early stages of T-cell maturation. 1 T-LBL patients show large mediastinal masses and no, or minimal (o25%), bone marrow involvement. These represent the main clinical features that discriminate the T-LBL from T-cell acute lymphoblastic leukemia (T-ALL) patients, who conversely display massive bone marrow involvement. Although major advances toward the understanding of T-ALL molecular pathogenesis have been achieved, similar studies in

T-LBL have been greatly impaired by the paucity of diagnostic tumor tissue available from pediatric T-LBL patients. We and others have started to investigate the molecular features of T-LBL by performing genomic and gene expression analyses. 2 These studies not only recognize a number of …