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Objectives: Cancer cachexia, a progressive wasting of adipose and skeletal muscle, frequently occurs in cancer patients and is responsible for up to 20% of cancer related deaths. Many cancer therapies neglect treating reductions in physical activity and muscle function, which are associated with increased risk of death. Naringenin is a phytochemical found in citrus fruits that has anti-inflammatory and anticancer activities and may promote physical activity and preserve muscle function. This study investigated whether naringenin could significantly improve locomotor activity and muscle function in mice with cancer cachexia.

Methods: Mice (16 male, CD2F1) were implanted with electronic telemetry transmitters prior to starting diets to continuously monitor locomotor activity. When mice were seven-to-eight weeks old, they were fed a semi-purified AIN 93-G diet supplemented with 2wt% naringenin (NAR) or without …