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Many unfortunate victims in road traffic crashes do not receive ideal treatment because their injury severity is not understood at an early stage. Swift crash severity prediction enables trauma and emergency centers to estimate the potential damage resulting from a road traffic crash and accordingly dispatch the proper emergency units to provide appropriate emergency treatment. A two-layer ensemble machine learning model is proposed in this study to predict road traffic crash severity. The first layer integrates four base machine learning models: k-nearest neighbor, decision tree, adaptive boosting, and support vector machine; the second layer classifies the crash severity based on the feedforward neural network model. The models are developed using road traffic crash data of road intersections over 6 years (2011-2016) obtained from Great Britain's Department of Transport online database. Only the crash features …