作者
Aaron K Styer, Susan Jin, Dan Liu, Baisong Wang, Alex J Polotsky, Mindy S Christianson, Wendy Vitek, Lawrence Engmann, Karl Hansen, Robert Wild, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Alicia Christy, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
发表日期
2017/3/1
期刊
Fertility and sterility
卷号
107
期号
3
页码范围
756-762. e3
出版商
Elsevier
简介
Objective
To investigate the association of non–cavity-distorting uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination (OS-IUI) in couples with unexplained infertility.
Design
Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes after OS-IUI.
Setting
Reproductive Medicine Network clinical sites.
Patient(s)
Nine hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial.
Intervention(s)
Participants were randomized to one of three arms (clomiphene citrate, letrozole, or gonadotropins), and treatment was continued for up to four cycles or until pregnancy was achieved.
Main Outcomes Measure(s)
Conception (serum hCG increase), clinical pregnancy (fetal cardiac activity), and live birth rates.
Result(s)
A total of 102/900 participants …
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