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Managers of highway bridge infrastructure constantly seek to improve their predictions of the physical performance of their facilities at any future time and also to identify the influential factors of bridge deterioration. In addressing this subject for concrete superstructures in particular, this paper uses empirical data from Indiana spanning 1992–2014. The superstructure design types considered are cast-in-place concrete (slab, stringer, and arch-deck) and prestressed concrete (stringer, T-beam, box-beam multiple, and box-beam single). Exponential and polynomial functional forms are investigated as part of the modeling process. A number of factors are found to have statistically significant influence on the deterioration of the concrete superstructures’ physical condition consistently across all design types, and other factors are found to be significant only for some design types. The paper also carries out sensitivity and …