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The language of medical research appears to be intrinsically tied to the culture of medical research and provides a unique window into broader trends in the culture of medicine.

To analyze medical language from 5 premier medical journals and investigate broader changes in the culture of clinical investigation during the last 40 years.

In this qualitative study using a data-driven analysis, 302 293 PubMed records were extracted fromJAMA,The Lancet,Annals of Internal Medicine, theBMJ, andNew England Journal of Medicinefrom January 1, 1976, through December 31, 2015, to identify key trends in medical language. A frequency analysis was applied across the 40-year time frame inJAMAto assess the major trends in all publication types. Patient-centered language was analyzed in clinical trials in the flanking time periods (1976-1980 and 2011-2015) across the 5 …