作者
Dorothea Lilli Floris, Thomas Wolfers, Mariam Zabihi, Nathalie E Holz, Marcel P Zwiers, Tony Charman, Julian Tillmann, Christine Ecker, Flavio Dell'Acqua, Tobias Banaschewski, Carolin Moessnang, Simon Baron-Cohen, Rosemary Holt, Sarah Durston, Eva Loth, Declan GM Murphy, Andre Marquand, Jan K Buitelaar, Christian F Beckmann
发表日期
2020/1/1
出版商
Cold Spring Harbor Laboratory
简介
Background
Autism spectrum disorder (“autism”) is a highly heterogeneous neurodevelopmental condition with few effective treatments for core and associated features. To make progress we need to both identify and validate neural markers that help to parse heterogeneity to tailor therapies to specific neurobiological profiles. Atypical hemispheric lateralization is a stable feature across studies in autism, but its potential as a neural stratification marker has not been widely examined.
Methods
In order to dissect heterogeneity in lateralization in autism, we used the large EU-AIMS (European Autism Interventions—A Multicentre Study for Developing New Medications) Longitudinal European Autism Project dataset comprising 352 individuals with autism and 233 neurotypical control subjects as well as a replication dataset from ABIDE (Autism Brain Imaging Data Exchange) (513 individuals with autism, 691 neurotypical …
学术搜索中的文章
DL Floris, T Wolfers, M Zabihi, NE Holz, MP Zwiers… - Biological Psychiatry: Cognitive Neuroscience and …, 2021