作者
Andre F Marquand, Thomas Wolfers, Maarten Mennes, Jan Buitelaar, Christian F Beckmann
发表日期
2016/9/1
来源
Biological psychiatry: cognitive neuroscience and neuroimaging
卷号
1
期号
5
页码范围
433-447
出版商
Elsevier
简介
Heterogeneity is a key feature of all psychiatric disorders that manifests on many levels, including symptoms, disease course, and biological underpinnings. These form a substantial barrier to understanding disease mechanisms and developing effective, personalized treatments. In response, many studies have aimed to stratify psychiatric disorders, aiming to find more consistent subgroups on the basis of many types of data. Such approaches have received renewed interest after recent research initiatives, such as the National Institute of Mental Health Research Domain Criteria and the European Roadmap for Mental Health Research, both of which emphasize finding stratifications that are based on biological systems and that cut across current classifications. We first introduce the basic concepts for stratifying psychiatric disorders and then provide a methodologically oriented and critical review of the existing …
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AF Marquand, T Wolfers, M Mennes, J Buitelaar… - Biological psychiatry: cognitive neuroscience and …, 2016