作者
Hyun ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H Bortz III, Ariel S Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M Eugenia Dieterle, Rohit K Jangra, J Maximilian Fels, Karen Tong, Margarette C Mariano, Olivia Vergnolle, George I Georgiev, Natalia G Herrera, Ryan J Malonis, Jose A Quiroz, Nicholas C Morano, Gregory J Krause, Joseph M Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y Goldstein, Joan Uehlinger, Scott J Garforth, Steven C Almo, Jonathan R Lai, Morayma Reyes Gil, Amy S Fox, Kartik Chandran, Tao Wang, Johanna P Daily, Liise-anne Pirofski
发表日期
2021/2/22
期刊
JCI insight
卷号
6
期号
4
出版商
American Society for Clinical Investigation
简介
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200 mL of CCP with a spike protein IgG titer≥ 1: 2430 (median 1: 47,385) within 72 hours of admission with propensity score–matched controls cared for at a medical center in the Bronx, between April 13 and May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroid use, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared with matched controls, CCP recipients less than 65 years had 4-fold lower risk of …
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H ah Yoon, R Bartash, I Gendlina, J Rivera, A Nakouzi… - JCI insight, 2021