作者
Nicolás A Muena, Tamara García-Salum, Catalina Pardo-Roa, María José Avendaño, Eileen F Serrano, Jorge Levican, Leonardo I Almonacid, Gonzalo Valenzuela, Estefany Poblete, Shirin Strohmeier, Erick Salinas, Andres Muñoz, Denise Haslwanter, Maria Eugenia Dieterle, Rohit K Jangra, Kartik Chandran, Claudia González, Arnoldo Riquelme, Florian Krammer, Nicole D Tischler, Rafael A Medina
发表日期
2022/4/1
期刊
EBioMedicine
卷号
78
页码范围
103972
出版商
Elsevier
简介
Background
A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses in naturally infected individuals in Chile and compared them to humoral responses induced after immunization with CoronaVac-based on an inactivated whole virus -or the BNT162b2- based on mRNA-vaccines. We also contrasted them with the respective effectiveness and efficacy data available for both vaccines.
Methods
We determined and compared the longitudinal neutralizing (nAb) and anti-nucleocapsid (anti-N) antibody responses of 74 COVID-19 individuals (37 outpatient and 37 hospitalized) during the acute disease and convalescence. We also assessed the antibody boosting of 36 of these individuals who were immunized after convalescence with either the CoronaVac (n = 30) or the BNT162b2 …
学术搜索中的文章
NA Muena, T García-Salum, C Pardo-Roa… - EBioMedicine, 2022