作者
Xiaoyan Hui, Huiying Li, Zhiguang Zhou, Karen SL Lam, Yang Xiao, Donghai Wu, Ke Ding, Yu Wang, Paul M Vanhoutte, Aimin Xu
发表日期
2010/4/2
期刊
Journal of Biological Chemistry
卷号
285
期号
14
页码范围
10273-10280
出版商
Elsevier
简介
Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation remain elusive. Here, we report that A-FABP forms a finely tuned positive loop between JNK and activator protein-1 (AP-1) to exacerbate lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Real time PCR and luciferase reporter analysis showed that LPS induced A-FABP expression through transcriptional activation. This effect was mediated by JNK, which promoted the recruitment of c-Jun to a highly conserved AP-1 consensus binding motif located within the proximal region of the A-FABP promoter. LPS-induced transactivation of the A …
引用总数
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