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Brain structural alterations are consistently reported in depressive disorders, yet it remains unclear whether these alterations reflect a pre-existing vulnerability or are the result of psychopathology. We aimed to investigate prospective adolescent neurodevelopmental risk markers for depressive disorder onset, using data from a fifteen-year longitudinal study. A risk-enriched community sample of 161 adolescents who had no history of depressive disorders participated in neuroimaging assessments conducted during early (age 12), mid (age 16) and late adolescence (age 19). Onsets of depressive disorders were assessed for the period spanning early adolescence through emerging adulthood (post-baseline, ages 12 to 27). Forty-six participants (28 female) experienced a first episode of a depressive disorder during the follow-up period; eighty-three participants (36 female) received no mental disorder diagnosis …