作者
Fatemeh Dehghani Firouzabadi, Javad Salimi, Aliakbar Amirzargar, Mohammad Dehghani Firouzabadi, Hani Arbabi, Seyyed M. Mousavizadeh, Kambiz Izadpanh
发表日期
2020/6/21
期刊
Immunity, Inflammation and Disease
出版商
Wiley online library
简介
Objective
The aim of this study was to investigate the human leukocyte antigen (HLA) class I (HLA‐A and HLA‐B) and II (HLA‐DRB1) allele and haplotype frequencies in a group of Iranian patients with Buerger's disease (BD) in comparison with a normal healthy control group.
Methods
A total of 70 unrelated male patients and 100 healthy controls from Sina Hospital, Tehran, Iran, belonging to the same ethnic background, were enrolled in this case‐control study. HLA‐A, B, and DRB1 typing were performed by polymerase chain reaction with sequence‐specific primers (PCR‐SSP).
Results
The results of this case‐control study showed that the frequency of the HLA‐A*03:01 (odds ratio (OR) = 2.88, P value (Pv) = .002), HLA‐A*29:01 (OR = 15.31, Pv < .001), HLA‐DRB1*04:02 (OR = 3.41, Pv < .001), and HLA‐DRB1*16:01 (OR = 8.16, Pv < .001) was significantly higher in BD patients compared …
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F Dehghani Firouzabadi, J Salimi, A Amirzargar… - Immunity, Inflammation and Disease, 2020