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Cumin is an annual herb from Apiaceae family. Cumin seeds possess good content of phenolic compounds which show considerable free radical scavenging activity. Nanoemulsions (NEs) can be used as a vehicle for transport of pharmaceutical phytochemicals through the stratum corneum barrier because of their stability and rapid permeation properties. The objective of this work is to encapsulate cumin essential oil (CEO) in transdermal nanoemulsion formulations to acquire efficient and prolonged systemic antioxidant and hepatoprotective activities. Six phase diagrams were constructed comprising Capryol™ 90 or oleic acid as the oil phase along with three surfactant/co-surfactant (Smix) ratios; 1:1, 2:1, and 3:1 of Tween 20/ethanol. From each, one nanoemulsion system was selected. The prepared CEO loaded NEs showed high phenolic encapsulation efficiency as well as remarkable cumulative phenols …