作者
Nishant Agrawal, Rehan Akbani, B Arman Aksoy, Adrian Ally, Harindra Arachchi, Sylvia L Asa, J Todd Auman, Miruna Balasundaram, Saianand Balu, Stephen B Baylin, Madhusmita Behera, Brady Bernard, Rameen Beroukhim, Justin A Bishop, Aaron D Black, Tom Bodenheimer, Lori Boice, Moiz S Bootwalla, Jay Bowen, Reanne Bowlby, Christopher A Bristow, Robin Brookens, Denise Brooks, Robert Bryant, Elizabeth Buda, Yaron SN Butterfield, Tobias Carling, Rebecca Carlsen, Scott L Carter, Sally E Carty, Timothy A Chan, Amy Y Chen, Andrew D Cherniack, Dorothy Cheung, Lynda Chin, Juok Cho, Andy Chu, Eric Chuah, Kristian Cibulskis, Giovanni Ciriello, Amanda Clarke, Gary L Clayman, Leslie Cope, John A Copland, Kyle Covington, Ludmila Danilova, Tanja Davidsen, John A Demchok, Daniel DiCara, Noreen Dhalla, Rajiv Dhir, Sheliann S Dookran, Gideon Dresdner, Jonathan Eldridge, Greg Eley, Adel K El-Naggar, Stephanie Eng, James A Fagin, Timothy Fennell, Robert L Ferris, Sheila Fisher, Scott Frazer, Jessica Frick, Stacey B Gabriel, Ian Ganly, Jianjiong Gao, Levi A Garraway, Julie M Gastier-Foster, Gad Getz, Nils Gehlenborg, Ronald Ghossein, Richard A Gibbs, Thomas J Giordano, Karen Gomez-Hernandez, Jonna Grimsby, Benjamin Gross, Ranabir Guin, Angela Hadjipanayis, Hollie A Harper, D Neil Hayes, David I Heiman, James G Herman, Katherine A Hoadley, Matan Hofree, Robert A Holt, Alan P Hoyle, Franklin W Huang, Mei Huang, Carolyn M Hutter, Trey Ideker, Lisa Iype, Anders Jacobsen, Stuart R Jefferys, Corbin D Jones, Steven JM Jones, Katayoon Kasaian, Electron Kebebew, Fadlo R Khuri, Jaegil Kim, Roger Kramer, Richard Kreisberg, Raju Kucherlapati, David J Kwiatkowski, Marc Ladanyi, Phillip H Lai, Peter W Laird, Eric Lander, Michael S Lawrence, Darlene Lee, Eunjung Lee, Semin Lee, William Lee, Kristen M Leraas, Tara M Lichtenberg, Lee Lichtenstein, Pei Lin, Shiyun Ling, Jinze Liu, Wenbin Liu, Yingchun Liu, Virginia A LiVolsi, Yiling Lu, Yussanne Ma, Harshad S Mahadeshwar, Marco A Marra, Michael Mayo, David G McFadden, Shaowu Meng, Matthew Meyerson, Piotr A Mieczkowski, Michael Miller, Gordon Mills, Richard A Moore, Lisle E Mose, Andrew J Mungall, Bradley A Murray, Yuri E Nikiforov, Michael S Noble, Akinyemi I Ojesina, Taofeek K Owonikoko, Bradley A Ozenberger, Angeliki Pantazi, Michael Parfenov, Peter J Park, Joel S Parker, Evan O Paull, Chandra Sekhar Pedamallu, Charles M Perou, Jan F Prins, Alexei Protopopov
发表日期
2014/10/23
期刊
Cell
卷号
159
期号
3
页码范围
676-690
出版商
Elsevier
简介
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of genomic variants, gene expression, and methylation demonstrated that different driver groups lead to different pathologies with distinct signaling and differentiation characteristics. Similarly, we identified distinct molecular subgroups of BRAF-mutant tumors, and multidimensional analyses highlighted a potential involvement of oncomiRs in less-differentiated subgroups. Our results propose a reclassification of thyroid cancers into molecular subtypes that …
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