作者
Patricia A Boyle, Aron S Buchman, Robert S Wilson, Sue E Leurgans, David A Bennett
发表日期
2009/11/9
期刊
Archives of neurology
卷号
66
期号
11
页码范围
1339-1344
出版商
American Medical Association
简介
Background
Loss of muscle strength is common and is associated with various adverse health outcomes in old age, but few studies have examined the association of muscle strength with the risk of Alzheimer disease (AD) or mild cognitive impairment (MCI).
Objective
To test the hypothesis that muscle strength is associated with incident AD and MCI.
Design
Prospective observational cohort study.
Setting
Retirement communities across the Chicago, Illinois, metropolitan area.
Participants
More than 900 community-based older persons without dementia at the baseline evaluation and in whom strength was measured in 9 muscle groups in arms and legs, and in the axial muscles and summarized into a composite measure of muscle strength.
Main Outcome Measures
Incident AD and MCI and the rate of change in global cognitive function.
Results
During a mean follow-up of 3.6 years, 138 persons developed AD. In a …
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