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Denial of service attacks pose a threat in constant growth. This is mainly due to their tendency to gain in sophistication, ease of implementation, obfuscation and the recent improvements in occultation of fingerprints. On the other hand, progress towards self-organizing networks, and the different techniques involved in their development, such as software-defined networking, network-function virtualization, artificial intelligence or cloud computing, facilitates the design of new defensive strategies, more complete, consistent and able to adapt the defensive deployment to the current status of the network. In order to contribute to their development, in this paper, the use of artificial immune systems to mitigate denial of service attacks is proposed. The approach is based on building networks of distributed sensors suited to the requirements of the monitored environment. These components are capable of identifying threats …