作者
Michael Stahl, Martin K Walz, Martin Stuschke, Nils Lehmann, Hans-Joachim Meyer, Jorge Riera-Knorrenschild, Peter Langer, Rita Engenhart-Cabillic, Michael Bitzer, Alfred Königsrainer, Wilfried Budach, Hansjochen Wilke
发表日期
2009/2/20
期刊
Journal of clinical oncology
卷号
27
期号
6
页码范围
851-856
出版商
American Society of Clinical Oncology
简介
Purpose
Preoperative chemotherapy is an accepted standard in the treatment of localized esophagogastric adenocarcinoma. Adding radiation therapy to preoperative chemotherapy appears promising, but its definitive value remains unknown.
Patients and Methods
Patients with locally advanced (uT3-4NXM0) adenocarcinoma of the lower esophagus or gastric cardia were randomly allocated to one of two treatment groups: induction chemotherapy (15 weeks) followed by surgery (arm A); or chemotherapy (12 weeks) followed by chemoradiotherapy (3 weeks) followed by surgery (arm B). Primary outcome was overall survival time. A total of 354 patients were needed to detect a 10% increase in 3-year survival from 25% to 35% by addition of radiation therapy. The study was prematurely closed due to low accrual.
Results
The median observation time was 46 months. A total of 126 patients were randomly assigned …
引用总数
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M Stahl, MK Walz, M Stuschke, N Lehmann, HJ Meyer… - Journal of clinical oncology, 2009