作者
Marco Baron Toaldo, Veronica Salvatore, Sara Marinelli, Chiara Palamà, Maddalena Milazzo, Luca Croci, Laura Venerandi, Mario Cipone, Luigi Bolondi, Fabio Piscaglia
发表日期
2015/2
期刊
Molecular imaging and biology
卷号
17
页码范围
29-37
出版商
Springer US
简介
Purpose
The aim of this study was to assess the early response to sorafenib using ultrasound molecular imaging in a murine model of hepatocellular carcinoma (HCC).
Procedures
A xenograft model of HCC was established. Then, mice were divided in two groups and received treatment (sorafenib) or placebo for 14 days. The treatment group was further divided into non-responders and responders according to the degree of growth. Contrast enhanced ultrasound (CEUS) was performed using VEGFR-2 targeted microbubbles (BR55, Bracco Suisse SA, Geneva, Switzerland). Dedicated software was used to quantify the amount of bound microbubbles in the tumor as a numerical value (differential targeted enhancement (dTE)). Tumors were then excised and western blot analysis performed.
Results
The dTE values …
学术搜索中的文章
M Baron Toaldo, V Salvatore, S Marinelli, C Palamà… - Molecular imaging and biology, 2015