作者
Noémie Gensous, Claudio Franceschi, Aurelia Santoro, Maddalena Milazzo, Paolo Garagnani, Maria Giulia Bacalini
发表日期
2019/4/24
来源
International journal of molecular sciences
卷号
20
期号
8
页码范围
2022
出版商
MDPI
简介
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications.
学术搜索中的文章
N Gensous, C Franceschi, A Santoro, M Milazzo… - International journal of molecular sciences, 2019