作者
Noémie Gensous, Paolo Garagnani, Aurelia Santoro, Cristina Giuliani, Rita Ostan, Cristina Fabbri, Maddalena Milazzo, Davide Gentilini, Anna Maria di Blasio, Barbara Pietruszka, Dawid Madej, Agata Bialecka-Debek, Anna Brzozowska, Claudio Franceschi, Maria Giulia Bacalini
发表日期
2020/4
期刊
Geroscience
卷号
42
页码范围
687-701
出版商
Springer International Publishing
简介
Mediterranean diet has been proposed to promote healthy aging, but its effects on aging biomarkers have been poorly investigated. We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath’s clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention. The effect was statistically significant in the group of Polish females and in subjects who were epigenetically older at baseline. A genome-wide association study of epigenetic age changes after the intervention did not return significant (adjusted p value < 0.05) loci. However, we identified small-effect alleles (nominal p value < 10–4), mapping in genes enriched in pathways related to energy metabolism, regulation of cell cycle, and of immune …
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N Gensous, P Garagnani, A Santoro, C Giuliani… - Geroscience, 2020