作者
Mordhwaj S Parihar, Arti Parihar, Frederick A Villamena, Patrick S Vaccaro, Pedram Ghafourifar
发表日期
2008/3/21
期刊
Biochemical and biophysical research communications
卷号
367
期号
4
页码范围
761-767
出版商
Academic Press
简介
We recently demonstrated that mitochondrial nitric oxide synthase (mtNOS) functionally couples with mitochondrial respiratory chain complex I to produce nitric oxide [M.S. Parihar, R.R. Nazarewicz, E. Kincaid, U. Bringold, P. Ghafourifar, Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I, Biochem. Biophys. Res. Commun. 366 (2008) 23–28] [1]. The present report shows that inactivation of complex I leads mtNOS to become pro-oxidative. Our findings suggest a crucial role for mtNOS in oxidative stress caused by mitochondrial complex I inactivation.
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MS Parihar, A Parihar, FA Villamena, PS Vaccaro… - Biochemical and biophysical research communications, 2008