作者
Thomas S Wingo, Yue Liu, Ekaterina S Gerasimov, Jake Gockley, Benjamin A Logsdon, Duc M Duong, Eric B Dammer, Adriana Lori, Paul J Kim, Kerry J Ressler, Thomas G Beach, Eric M Reiman, Michael P Epstein, Philip L De Jager, James J Lah, David A Bennett, Nicholas T Seyfried, Allan I Levey, Aliza P Wingo
发表日期
2021/6
期刊
Nature neuroscience
卷号
24
期号
6
页码范围
810-817
出版商
Nature Publishing Group US
简介
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization. We identified 19 genes that were consistent with being causal in depression, acting via their respective cis-regulated brain protein abundance. We replicated nine of these genes using an independent depression GWAS (N = 307,353) and another human brain proteomic dataset (N = 152). Eleven of the 19 genes also had cis-regulated mRNA levels that were associated with depression, based on integration of the depression GWAS with human brain transcriptomes (N = 888). Meta-analysis of the discovery and replication proteome-wide …
学术搜索中的文章
TS Wingo, Y Liu, ES Gerasimov, J Gockley… - Nature neuroscience, 2021