作者
Cornelius A Rietveld, Tõnu Esko, Gail Davies, Tune H Pers, Patrick Turley, Beben Benyamin, Christopher F Chabris, Valur Emilsson, Andrew D Johnson, James J Lee, Christiaan de Leeuw, Riccardo E Marioni, Sarah E Medland, Michael B Miller, Olga Rostapshova, Sven J Van Der Lee, Anna AE Vinkhuyzen, Najaf Amin, Dalton Conley, Jaime Derringer, Cornelia M Van Duijn, Rudolf Fehrmann, Lude Franke, Edward L Glaeser, Narelle K Hansell, Caroline Hayward, William G Iacono, Carla Ibrahim-Verbaas, Vincent Jaddoe, Juha Karjalainen, David Laibson, Paul Lichtenstein, David C Liewald, Patrik KE Magnusson, Nicholas G Martin, Matt McGue, George McMahon, Nancy L Pedersen, Steven Pinker, David J Porteous, Danielle Posthuma, Fernando Rivadeneira, Blair H Smith, John M Starr, Henning Tiemeier, Nicholas J Timpson, Maciej Trzaskowski, André G Uitterlinden, Frank C Verhulst, Mary E Ward, Margaret J Wright, George Davey Smith, Ian J Deary, Magnus Johannesson, Robert Plomin, Peter M Visscher, Daniel J Benjamin, David Cesarini, Philipp D Koellinger
发表日期
2014/9/23
期刊
Proceedings of the National Academy of Sciences
卷号
111
期号
38
页码范围
13790-13794
出版商
National Academy of Sciences
简介
We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1 …
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CA Rietveld, T Esko, G Davies, TH Pers, P Turley… - Proceedings of the National Academy of Sciences, 2014