作者
Tina Bagratuni, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Nefeli Mavrianou-Koutsoukou, Christine Liacos, Dimitrios Patseas, Nikolaos Kanellias, Magdalini Migkou, Dimitrios C Ziogas, Evangelos Eleutherakis-Papaiakovou, Maria Roussou, Despina Fotiou, Evangelos Terpos, Efstathios Kastritis, Meletios A Dimopoulos
发表日期
2018/12
期刊
Leukemia
卷号
32
期号
12
页码范围
2617-2625
出版商
Nature Publishing Group UK
简介
Liquid biopsyis being integrated into cancer diagnostics with profound therapeutic implications. However, its role in Waldenström’s Macroglobulinemia (WM) and IgM monoclonal gammopathies is still unclear. In this study, we evaluated the role of peripheral blood (PB) cell-free DNA (cfDNA) in characterizing the mutational status of MYD88 and CXCR4 of patients with IgM monoclonal gammopathies. Paired bone marrow (BM) tumor DNA (tDNA) and PB cfDNA samples from 98 patients (9 MGUS, 45 with WM in remission, 44 with smoldering WM, newly diagnosed or relapsed WM) and 10 controls with non-IgM monoclonal gammopathies were analyzed. Regarding MYD88L265P mutation, 76 patients had paired tDNA and cfDNA informative samples. Among patients with WM in remission, 65% harbored the MYD88L265P mutation, whereas the corresponding percentage among smoldering/newly diagnosed or …
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Detection of MYD88 and CXCR4 mutations in cell-free DNA of patients with IgM monoclonal gammopathies
T Bagratuni, I Ntanasis-Stathopoulos… - Leukemia, 2018