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Besides being a hard combinatorial problem, the VRP is also a spatial problem. Hence, effective decision making in this field strongly requires the integration of GIS and optimization systems (GIS-O). This article integrates GIS and optimization tools for solving the vehicle routing problem with loading and distance requirements (DCVRP). A general outline of the multi-step integration is pointed out showing the interaction of the GIS and the spatial optimization according to the loose coupling strategy. The computational performance of the TS-VRP algorithm for the DCVRP turned out to be quite efficient on both computation time and solution quality. The Tunisian case study well illustrates the incentive behind using such a spatial decision support system that allows the management of the problem from the data acquisition to the visualization of possible simulation scenarios in a more realistic way.