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the onset of acute kidney injury (AKI). This scenario increases the vulnerability of patients with DKD to advanced stages of the disease. The practice of physical exercise (PE) is anon-pharmaco-logical intervention that attenuates the complications of DKD and suppresses its morbidity. Aim: Evaluate the effect of PE on renal function, hemo-dynamics, oxidative profile and histology in rats with DKD treated with PmB. Method: Male and adult Wistar rats weighing 280–300 g, animals groups: Citrate (CT): animals that received (citrate; iv, caudal, single dose); Citrate+ Physical Exercise (PE): citrate animals submitted to swimming training, daily, for 1 hour, for 4 weeks; Diabetes Mellitus (DM): animals that received STZ (60 mg/kg; iv, caudal); DM+ PE: DM and underwent PE; DM+ PmB: DM animals that received PmB (4 mg/kg/day, ip, 1×day, 5 days); DM+ EF+ PmB: animals DM who received PmB and underwent PE …