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Mucuna pruriens (MP) L. and Coriandrum sativum (CS) have been found for in vitro antithrombotic activity. However, the in vivo studies for both plants have not been discovered yet. The objective of the study is to prove the efficacy of MP L. and CS by conducting in vivo antithrombotic activity test with bleeding time and survival rate as the parameters. MP and CS extracts with three different doses were given orally to the experimental animals for 7 days. Aspirin was used as a positive control. The bleeding time was observed on mice tail that had been cut, and the survival rate was determined by inducing thrombosis with collagen–epinephrine injection. Seven-day treatment of plant extracts significantly prolonged the bleeding time of the treated group compared to the normal control group. The result demonstrated the increasing number of survived animals in the treated group compared to the negative control group. Both extracts had shown antithrombotic activity by significantly prolonged the bleeding time and increased the survival rate.