查看文章

Kidney disease was ranked 10th as the leading cause of death in Indonesia according to WHO Country Health Profiles in 2012. In conducting alternative therapies research, preclinic study using animal model is performed before the drug can be tested into human beings. This study was designed to investigate alternative therapies on kidney disease and to evaluate nephrotoxicity in rat models. Evaluation of nephrotoxicity in rat models is conducted using 27 rats which divided into 7 groups: normal, 3 groups of gentamycin (80, 100, and 120 mg/kg w/day), and 3 groups of diclofenac sodium (10, 50, and 100 mg/kg w/day). Meanwhile, to evaluate the therapeutic effect of losartan, 3 dosage variations (5, 10, and 20 mg/kg w/day) were given to the nephrotoxic rat model. Induction of gentamycin elevated the levels of serum creatinine, BUN, and the relative kidney …