作者
Didac Santesmasses, José Pedro Castro, Aleksandr A Zenin, Anastasia V Shindyapina, Maxim V Gerashchenko, Bohan Zhang, Csaba Kerepesi, Sun Hee Yim, Peter O Fedichev, Vadim N Gladyshev
发表日期
2020/10
期刊
Aging cell
卷号
19
期号
10
页码范围
e13230
简介
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to preferentially target older subjects and those with pre‐existing conditions, but the reason for this age dependence is unclear. Here, we found that the case fatality rate for COVID‐19 grows exponentially with age in all countries tested, with the doubling time approaching that of all‐cause human mortality. In addition, men and those with multiple age‐related diseases are characterized by increased mortality. Moreover, similar mortality patterns were found for all‐cause pneumonia. We further report that the gene expression of ACE2, the SARS‐CoV‐2 receptor, grows in the lung with age, except for subjects on a ventilator. Together, our findings establish COVID‐19 as an emergent disease of aging, and age and age‐related diseases as its …
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