查看文章

S. Etzion, A. Battler, I. M. Barbash, E. Cagnano, P. Zarin, Y. Granot, L. H. Kedes, R. A. Kloner and J. Leor. Influence of Embryonic Cardiomyocyte Transplantation on the Progression of Heart Failure in a Rat Model of Extensive Myocardial Infarction. Journal of Molecular and Cellular Cardiology (2001) 33, 0000–0000. Cell transplantation has been proposed as a future therapy for various myocardial diseases. It is unknown, however, whether the encouraging results obtained in animal models of ischemia and reperfusion, cryoinjury or cardiomyopathy can be reproduced in the setting of permanent coronary artery occlusion and extensive myocardial infarction (MI). Embryonic cardiac cells were isolated and cultured for 3 days to confirm viability, morphology and to label cells with BrdU or the reporter gene LacZ. Seven days after extensive MI, rats were randomized to cell (1.5×10⁶) transplantation (n=11) or culture …