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Close monitoring of mucosal inflammation in Crohn’s disease [CD] is paramount to objectively evaluate therapeutic responses and make informed therapeutic decisions. 1 While undergoing recurrent endoscopies is inconvenient to most patients, other available monitoring tools such as C-reactive protein and faecal calprotectin demonstrate inconsistent correlation with endoscopic disease activity and also lack specificity, 2, 3 or are not yet globally available such as with intestinal ultrasound.

Hamilton and colleagues have evaluated the performance of a serum proteomic multi-marker panel [the Endoscopic Healing Index, EHI] in monitoring for postoperative disease recurrence [POR]. 4 At 6 months postoperatively, EHI values in patients with recurrence were significantly higher than in those with no recurrence. Additionally, longitudinal changes