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METHODS:

Serum samples paired with endoscopic data from consecutive adult patients with UC initiating advanced therapy for active disease (Mayo Endoscopic Subscore [MES]> 1) were analyzed. EHI values were compared between groups showing endoscopic improvement, remission, and nonresponse, defined, respectively, as MES of≤ 1, 0 and> 1. We also assessed the association of EHI with longitudinal changes of MES and compared its performance with that of fecal calprotectin (FC) and C-reactive protein.

RESULTS:

A total of 127 patients provided 303 samples. Median EHI increased significantly with increasing MES score (P< 0.001). Median EHI was significantly lower in patients with endoscopic remission or improvement compared with patients with no response (P< 0.001, P< 0.001, respectively). A 10-point decrease in EHI was associated with 89% higher odds of 1-point decrease in MES (P< 0.001 …