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This paper presents details and applications of a novel channel simulation software named NYUSIM, which can be used to generate realistic temporal and spatial channel responses to support realistic physical-and link-layer simulations and design for fifth-generation (5G) cellular communications. NYUSIM is built upon the statistical spatial channel model for broadband millimeter-wave (mmWave) wireless communication systems developed by researchers at New York University (NYU). The simulator is applicable for a wide range of carrier frequencies (500 MHz to 100 GHz), radio frequency (RF) bandwidths (0 to 800 MHz), antenna beamwidths (7° to 360° for azimuth and 7° to 45° for elevation), and operating scenarios (urban microcell, urban macrocell, and rural macrocell), and also incorporates multiple-input multiple-output (MIMO) antenna arrays at the transmitter and receiver. This paper also provides …