作者
Lei Fu, Rong Wang, Ling Yin, Xiaopu Shang, Runtong Zhang, Pengjun Zhang
发表日期
2019/9
期刊
The International journal of biological markers
卷号
34
期号
3
页码范围
251-261
出版商
SAGE Publications
简介
Objective
The aim of the study was to evaluate the diagnostic value of soluble fragment of cytokeratin 19 (CYFRA21-1) tests in detecting non-small cell lung cancer (NSCLC), including squamous cell carcinoma, lung adenocarcinoma, and large cell carcinoma.
Methods
The relevant studies were identified from PubMed, Embase and the Cochrane Library before November 2018. Summary estimates for sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of CYFRA21-1 tests for the diagnosis of NSCLC were calculated using the random effects model. A summary receiver operating characteristic (SROC) curve was used to assess the overall effectiveness of the test. Meta-DiSc 1.4 and Stata11.0 were applied to the statistical analysis. Publication bias was detected using Egger’s test.
Results
A total of 22 studies consisting of 7910 NSCLC patients (squamous cell carcinoma …
学术搜索中的文章
L Fu, R Wang, L Yin, X Shang, R Zhang, P Zhang - The International journal of biological markers, 2019